Induction of choline rise in the rat hippocampus by electroconvulsive shock treatment
نویسندگان
چکیده
Human hippocampal choline decreases in major depression episodes. This decrease was recently measured by our group and it has been found that its level normalizes during electroconvulsive therapy. We hypothesized a hippocampal choline increase in the rat brain under electroconvulsive shock (ECS) treatment in an animal model of depression (Learned Helplessness). Method: Rat hippocampi were investigated via magnetic resonance spectroscopy before and after 6 ECS treatments. Results: After ECS treatment hippocampal choline increases significantly. Conclusions: Our results are in good agreement with reported ECS induced hippocampal mossy fiber sprouting, synaptic plasticity and neurogenesis and with the findings in human depression.
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